Spondyloarthritis
The Disease
Ankylosing Spondylitis (SpA) is a bone pathology that belongs to a superfamily of spondyloarthritides. SpA involves both axial and peripheral arthritis-like pathology characterized by inflammation and structural damage accompanied by new bone formation that may gradually lead to joint ankylosis.
In AS the primary site of inflammation is located at the enthesis or subchondral bone marrow with bone marrow oedema, infiltration of inflammatory cells and increased osteoclast density.
Evaluation Platform
Mice can be treated either early -at disease onset- or late –at established pathology. Disease progress and severity are assessed regularly using validated in vivo scoring scales for peripheral and axial pathology.
Read-Out Parameters
In vivo peripheral & axial pathology scoring
μCT imaging
Histopathological evaluation of joint and tail vertebrae sections
