Induced Disease Mouse Models
Induced disease models are critical tools for understanding pathological mechanisms, and evaluating the therapeutic potential of new treatments.
Disease induction is the result of the administration of chemicals or drugs that drive the development of conditions that mimic the pathophysiology of human diseases. Disease induction approaches are essential for diseases where genetic models may be less effective or difficult to establish. An added advantage is that induced models are relatively easy to develop, inexpesive, and can produce disease states relatively quickly offering the opportunity to use a variety of genetically modified mouse lines, including knockouts of the genes of interest and mice humanized for specific therapeutic targets.
Therefore, induced models are particularly useful in the preclinical phase of drug development, where potential drugs are tested for their ability to reduce disease symptoms or modify disease mechanisms.
